Cost Effective, Accurate, Specific, Mobile Biomarker Detection
Component Technologıes of the IACE Instrument
And How they will be Integrated
As illustrated on "The Proposed Solution" menu,the functionality and efficacy of the component technologies for the envisioned instrument have already been tested and proven. The next ımportant hurdle involves integrating all these proven technologies together into a workiing prototype.
The Core of the IACE Diagnostic Instrument
Schematic representation of a multi-capillary, multi-dimensional, multi-task, immunoaffinity, capillary electrophoresis. This instrument can be manufactured as a small portable design using a conventional capillary electrophoresis format or a microchip-microfluidic capillary electrophoresis format.
The principle of immunoaffinity capillary electrophoresis is based on capturing and isolating a substance of interest present in a complex mixture, in one dimension, by an affinity compound (e.g., an antibody) immobilized on the surface of a device named analyte concentrator-microreactor (ACM), and separate in a second dimension the one or more substances captured by and released from the immobilized antibody by a high-resolution technology named capillary electrophoresis.
Source: Guzman, J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1021: 14-29 (May 17).
The principle of immunoaffinity capillary electrophoresis is based on capturing and isolating a substance of interest present in a complex mixture, in one dimension, by an affinity compound (e.g., an antibody) immobilized on the surface of a device named analyte concentrator-microreactor (ACM), and separate in a second dimension the one or more substances captured by and released from the immobilized antibody by a high-resolution technology named capillary electrophoresis.
Source: Guzman, J Chromatogr B Analyt Technol Biomed Life Sci. 2016, 1021: 14-29 (May 17).